2'-OMe Modified and 2'-MOE Modified RNA Oligonucleotides

Oligonucleotides modified at the 2’-hydroxyl position by a methyl (OMe) or a methoxyethyl (MOE) group represent the second generation of nucleotide modifications for use as antisense agents.  Since antisense oligonucleotides composed of or containing these modifications display superior nuclease resistance in concert with lower toxicity (MOE) and slightly increased hybridization affinities, they have widely replaced the first generation class of phosphorothioate (PTO1) antisense oligonucleotides or they are used in combination with PTO backbone to fine tune the bioavailability.


In the past years, anti­sense oligo(ribo)nucleotides (ASOs) have re­ceived increasing attention in the devel­opment of drugs or as tools to study gene functions due to the presence of the genome sequences available for many model organisms and their ease to design and handle such molecules.


Microsynth provides the entire portfolio of antisense oligonucleotides in various synthesis scales (from nmol up to gram scale) and purifications. For more information about antisense oligonucleotides, please click here.


1 In PTO modifications, one of the non-bridging oxygen atoms in the phosphate backbone is replaced with a sulfur atom.

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