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Detection of Helicobacter pylori in Patients
Helicobacter pylori is a Gramnegative bacterium which is found to be present in the stomach-lining of ~3 billion people around the world. Although the majority of individuals infected with the bacterium experience no symptoms, it is linked with chronic gastritis, gastric ulcers and can promote stomach cancer. The spread of H. pylori is not known, but person-to-person transmission by either the oral-oral or fecal-oral route are believed to be most likely.
In the present project, Microsynth was asked to develop an assay for unambiguous diagnosis of H. pylori from oral biopsies and perform the testing of the biopsies. A major project challenge was to avoid the occurrence of false-negative results.