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RNA Oligonucleotides

RNA Oligonucleotides
 
 
Microsynth uses proprietary synthesizer technologies to offer RNA oligonucleotides of the highest quality. Our state-of-the-art production facilities enable fast synthesis of modified and non-modified RNA oligonucleotides.
 

Features and Benefits

 
 
High Quality
  • Stringent quality control (online trityl monitoring and MALDI-TOF MS or analytical PAGE)
  • Microsynth is a renowned supplier for top research institutes and pharma/biotech companies
 
Fast Production
  • Synthesis scales up to 1 µmol are shipped within 3 days
  • Standard modified oligos are shipped within 4 days

Excellent Technical Support
  • Our highly experienced and well-trained scientists are happy to support you

 

 
 
Cost Effective
  • Very competitive pricing
  • High guaranteed yields
 
Comprehensive Service Portfolio
  • Large range of synthesis scales (yields from nmol to µmol are available)
  • Broad range of 5’-, 3’- and internal modifications
  • 4 different purity levels
 
User-friendly Online Ordering System
  • User-friendly online portal with a series of helpful tools (e.g. order tracking & history, convenient search and re-order option)

Synthesis Scales


Microsynth is offering its RNA oligos at 5 different scales.
The available standard scales are Genomics, 0.04 µmol, 0.2 µmol, 1.0 µmol and 15 µmol.
As the yield and length restrictions depend also on the purification used please have a look at the tables below.

 


Desalted RNA Oligos 
Synthesis scale1 Length Restriction Guaranteed Yield2 Production Time [wd]
[OD260] [nmol]3
Genomics not available
0.04 µmol 10 - 30 4 21 2
0.2 µmol 10 - 50 8 35 2
1.0 µmol 10 - 50 18 80 2
15 µmol 10 - 40 400 1'800 3
 
HPLC Purified RNA Oligos 
Synthesis scale1 Length Restriction Guaranteed Yield2 Production Time [wd]
[OD260] [nmol]3
Genomics not available
0.04 µmol 10 - 30 1 5 2
0.2 µmol 10 - 50 3 15 2
1.0 µmol 13 65 2
15 µmol 10 - 40 300 1'500 4
 
IEX-HPLC Purified RNA Oligos 
Synthesis Scale1 Length Restriction Guaranteed Yield2 Production Time [wd]
[OD260] [nmol]5
Genomics not available
0.04 µmol not available
0.2 µmol 50 - 70 2 3.3 3-5
1.0 µmol 6 10 3-5
15 µmol not available
 
RP-HPLC Purified & Dialyzed RNA Oligos 
Synthesis scale1 Length Restriction Guaranteed Yield2 Production Time [wd]
[OD260] [nmol]3
Genomics not available
0.04 µmol not available
0.2 µmol 10 - 50 2 10 4
1.0 µmol 9 45 4
15 µmol 10 - 40 200 1'000 4
 
PAGE Purified RNA Oligos
Synthesis scale1 Length Restriction Guaranteed Yield2 Production Time [wd]
[OD260] [nmol]3
Genomics not available
0.04 µmol not available
0.2 µmol 10 - 50 1 5 2
1.0 µmol 10 - 50 6 30 2
15 µmol not available

 

1 The synthesis scale represents the initial amount of 3' bases (starting material).

2 Our guaranteed and average yields are measured in OD and are valid only for unmodified oligos >20 and <40 nucleotides.
3 Yields indicated in nmol represent an example calculation for a 20mer. For this calculation the following rule of thumb equation was applied: nmol of oligo = OD x 100/length of oligo. Please note that this calculation is based on sequences with virtually homogenous distribution of the 4 RNA bases.

 

Modifications

 

Microsynth offers a wide variety of modifications (5’, 3’ and internal) for DNA oligonucleotides. To give you a better overview, they have been categorized as: 

To learn more about the key specifications of a modification, please look at Modifications.

 

How to Order

 

  • Enter our webshop
  • Click on Single Stranded RNA in the "Oligonucleotide" domain
  • Select Normal Entry in order to type or copy/paste the desired sequence information etc. and follow the further instructions